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Thursday, July 16, 2020 | History

2 edition of TRP channels in health and disease found in the catalog.

TRP channels in health and disease

Arpad Szallasi

TRP channels in health and disease

implications for diagnosis and therapy

by Arpad Szallasi

  • 240 Want to read
  • 9 Currently reading

Published by Nova Science Publishers in Hauppauge, N.Y .
Written in English


Edition Notes

Includes bibliographical references and index.

Statementeditor, Arpad Szallasi
Classifications
LC ClassificationsQP552.T77 T767 2010
The Physical Object
Paginationp. ;
ID Numbers
Open LibraryOL24539098M
ISBN 109781616683375
LC Control Number2010025690
OCLC/WorldCa641540158

  Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly understood until recently. The goal of the present review is to summarize. Role of TRP ion channels in cancer and tumorigenesis Article (PDF Available) in Seminars in Immunopathology 38(3) February with Reads How we measure 'reads'.

Allergy and autoimmune diseases are characterised by a multifactorial pathogenic background. Several genes involved in the control of innate and adaptive immunity have been associated with diseases and variably combine with each other as well as with environmental factors and epigenetic processes to shape the characteristics of individual manifestations. Systemic or local perturbations in salt. TRP CHANNELS AS THERAPEUTIC TARGETS From Basic Science to Clinical Use Edited by Highjacking TRP Channels for Relief from Itch Lindsey M. Snyder,1,3,4 Huizhen Huang,1,3,5 Sarah E. Ross1,2,3,4,* Numerous diseases are associated with severe itch, including atopic dermatitis, liver disease.

Arpad Szallasi is the author of TRP Channels as Therapeutic Targets ( avg rating, 0 ratings, 0 reviews), Analgesia ( avg rating, 0 ratings, 0 revie. Mammalian Transient Receptor Potential (TRP) Cation Channels: Volume 1 - Ebook written by Bernd Nilius, Veit Flockerzi. Read this book using Google Play Books app on your PC, android, iOS devices. Download for offline reading, highlight, bookmark or take notes while you read Mammalian Transient Receptor Potential (TRP) Cation Channels: Volume 1.


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TRP channels in health and disease by Arpad Szallasi Download PDF EPUB FB2

Published: June (This book is a printed edition of the Special Issue TRP Channels in Health and Disease that was published in Cells). TRP Channels in Health and Disease: Implications for Diagnosis and Therapy (Medicine and Biology Research Developments): Medicine & Health Science Books @ This groundbreaking discovery led to the identification and characterization of several more proteins of the family of Transient Receptor Potential (TRP) ion channels.

Intensive research has provided us with the atomic structures of some of these proteins, as well as understanding of their physiological roles, both in normal and pathological by: 1. Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel, now named TRPC1, was cloned and published (reviewed in [ ] Next Article in Journal Onset of Telomere Dysfunction and Fusions in Human Ovarian CarcinomaCited by: 2.

This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists.

TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer.

TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume I presents a series of state-of-the-art minireviews on the most interesting TRP channels (from TRPA1 to TRPV4), as well as TRP-related protocols involving airways and the.

Most of the functionally characterized TRP channels are non-selective Ca 2+ -permeable cation channels. Only TRPM4 and TRPM5 are only permeable to monovalent cations but not to Ca 2+ or Mg 2+.

Two mammalian TRPs, TRPV5 and TRPV6, are highly Ca 2+ permeable. TRPM6 and TRPM7 are highly permeable to Mg 2+.Cited by:   Introduction to transient receptor potential (TRP) ion channels. TRP channels were discovered in the eye of the Drosophila melanogaster fly, and named for their transient response to bright light (Montell and Rubin, ).Several homologues have since been identified that have a well conserved ‘TRP domain’ consisting of 23–25 amino acids.

While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel : Hardcover.

There are strong indications that TRP channels are involved in many diseases. At this point, four channelopathies have been identified in which a defect in a TRP channel-encoding gene is the direct. The TRP superfamily is divided into seven subfamilies: the five group 1 TRPs (TRPC, TRPV, TRPM, TRPN, and TRPA) and two group 2 subfamilies (TRPP and TRPML).

TRP channels are important for human health as mutations in at least four TRP channels underlie disease. Ever since their identification, interest in the role of transient receptor potential (TRP) channels in health and disease has steadily increased. Robust evidence has underlined the role of TRP.

mutations in TRP channels that induce “loss-“ or “gain-of-function” of the channel and can be considered “disease-causing” have been identified. The role of TRPs will be further elucidated in complex diseases of the intestinal, renal, urogenital, respiratory, and cardiovascular systems.

TRP channels are polymodal channels in a true sense, in that most of the superfamily members can be activated by a multitude of stimuli. They were known to be vital for sensory physiology, but recent studies have established that TRP channels are crucial players in various other physiological and pathological conditions like cancer, renal physiology, cardiac health and neuronal by: 1.

Introduction. Asthma and chronic obstructive pulmonary disease (COPD) (a group of diseases including chronic bronchitis and emphysema) are now very common chronic diseases and there is evidence to suggest that the prevalence of both diseases is increasing worldwide (Manino and Buist,Pearce et al., ).COPD, in particular, is a major cause of mortality and morbidity globally.

TRP channels in disease. Nilius B(1). Author information: (1)KU Leuven, Department of Molecular Cell Biology, Division of Physiology, Laboratory of Ion Channel Research, Campus Gasthuisberg, Herestr busB Leuven, by: Changes in TRP channel expression or function are associated with a variety of diseases/disorders of the digestive system, notably gastro-esophageal reflux disease, inflammatory bowel disease, pain and hyperalgesia in heartburn, functional dyspepsia and irritable bowel syndrome, cholera, hypomagnesemia with secondary hypocalcemia, infantile hypertrophic pyloric stenosis, esophageal, gastrointestinal and.

Abstract. The transient receptor potential (TRP) channels are a large family of proteins with six main subfamilies termed the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and TRPA (ankyrin) groups.

Increasing evidence has implicated TRP channels in the pathology of diabetes, both on the level of insulin release from the pancreatic ß cells and in secondary conditions such as diabetic neuropathy, nephropathy, and vasculopathy. In this review, we summarize these recent findings. Previous chapter in book Next chapter in book.

Thus, TRP channels have emerged as promising novel therapeutic targets. Therefore, we explicitly place findings in this Cells Special Issue “Transient Receptor Potential (TRP) Ion Channels: From Development to Disease” that can be taken advantage of in creating new therapies for cardio-renal, vascular-metabolic, autoimmune, and neuronal.Book Title.

TRP Channels in Health and Disease: Implications for Diagnosis and Therapy; Start / End Page. - ; International Standard Book Number 13 .TRP channels are important for human health as mutations in at least four TRP channels underlie disease. is that a single TRP channel can be activated.